Plasminogen activator inhibitor activity in diarrhoea-associated haemolytic uraemic syndrome.

@article{Chant1994PlasminogenAI,
  title={Plasminogen activator inhibitor activity in diarrhoea-associated haemolytic uraemic syndrome.},
  author={I D Chant and David V. Milford and Peter E. Rose},
  journal={QJM : monthly journal of the Association of Physicians},
  year={1994},
  volume={87 12},
  pages={737-40}
}
In the haemolytic uraemic syndrome (HUS), platelet microthrombi and deposition of fibrin in glomeruli may contribute to the development of renal failure. The balance of procoagulant and fibrinolytic activities in the renal vasculature may therefore have an important role. We measured plasminogen-activator inhibitor (PAI) activity in the plasma of 81 children with diarrhoea-associated (D+) HUS, and found elevated PAI activity in many patients. When we categorized patients by need for dialysis… CONTINUE READING