Plasminogen activator inhibitor-1 regulates integrin alphavbeta3 expression and autocrine transforming growth factor beta signaling.

@article{Pedroja2009PlasminogenAI,
  title={Plasminogen activator inhibitor-1 regulates integrin alphavbeta3 expression and autocrine transforming growth factor beta signaling.},
  author={Benjamin S. Pedroja and Leah E. Kang and Alex Imas and Peter Carmeliet and Audrey M Bernstein},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 31},
  pages={20708-17}
}
Fibrosis is characterized by elevated transforming growth factor beta (TGFbeta) signaling, resulting in extracellular matrix accumulation and increased PAI-1 (plasminogen activator inhibitor) expression. PAI-1 induces the internalization of urokinase plasminogen activator/receptor and integrin alphavbeta3 from the cell surface. Since increased alphavbeta3 expression correlates with increased TGFbeta signaling, we hypothesized that aberrant PAI-1-mediated alphavbeta3 endocytosis could initiate… CONTINUE READING