Plasminogen activator inhibitor 1 promotes a poor prognosis in sepsis-induced disseminated intravascular coagulation.

@article{Madoiwa2006PlasminogenAI,
  title={Plasminogen activator inhibitor 1 promotes a poor prognosis in sepsis-induced disseminated intravascular coagulation.},
  author={Seiji Madoiwa and Shin Nunomiya and Takeharu Ono and Yuichi Shintani and Tsukasa Ohmori and Jun Mimuro and Yoichi Sakata},
  journal={International journal of hematology},
  year={2006},
  volume={84 5},
  pages={
          398-405
        }
}
Sepsis-induced disseminated intravascular coagulation (DIC) is a serious condition because it is closely linked to the development of multiple organ dysfunctions. We compared molecular fibrinolysis markers for 117 patients with sepsis-induced DIC and 1627 patients with nonseptic DIC. Levels of fibrinogen and fibrin degradation products and D-dimer were significantly lower in sepsis-induced DIC cases than in nonseptic DIC cases. In septic DIC cases, plasma plasminogen activator inhibitor 1 (PAI… CONTINUE READING
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