Plasminogen activator inhibitor-1 limits liver injury and facilitates regeneration after acetaminophen overdose.

@article{Bajt2008PlasminogenAI,
  title={Plasminogen activator inhibitor-1 limits liver injury and facilitates regeneration after acetaminophen overdose.},
  author={Mary Lynn Bajt and Hui-min Yan and Anwar Farhood and Hartmut Jaeschke},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2008},
  volume={104 2},
  pages={419-27}
}
Deficiency in plasminogen activator inhibitor-1 (PAI-1) gene expression is known to promote growth factor activation and regeneration in a number of hepatotoxicity models. To evaluate if PAI-1 has similar effects in acetaminophen (APAP) hepatotoxicity, wild-type (WT) and PAI-1 gene knockout mice (PAI-KO) were treated with 200 mg/kg APAP and liver injury and its repair were assessed. In WT animals, plasma alanine aminotransferase (ALT) activities increased during the first 12 h and then returned… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

Similar Papers

Loading similar papers…