Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence

@article{Kortlever2006PlasminogenAI,
  title={Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence},
  author={Roderik M. Kortlever and Paul J. Higgins and René Bernards},
  journal={Nature Cell Biology},
  year={2006},
  volume={8},
  pages={877-884}
}
p53 limits the proliferation of primary diploid fibroblasts by inducing a state of growth arrest named replicative senescence — a process which protects against oncogenic transformation and requires integrity of the p53 tumour suppressor pathway. However, little is known about the downstream target genes of p53 in this growth-limiting response. Here, we report that suppression of the p53 target gene encoding plasminogen activator inhibitor-1 (PAI-1) by RNA interference (RNAi) leads to escape… 

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