Plasminogen activator inhibitor 1 expression is regulated by the inflammatory mediators interleukin-1alpha, tumor necrosis factor-alpha, transforming growth factor-beta and oncostatin M in human cardiac myocytes.

Abstract

Accumulating evidence points towards a role for proteases and protease inhibitors in tissue remodelling and repair in a variety of organs. In particular-besides the matrix metalloprotease system-the plasminogen activator (PA)/plasmin system has been implicated in these processes in the heart. Urokinase type PA (u-PA) and PA inhibitor type 1 (PAI-1) seem to… (More)

Topics

Cite this paper

@article{Macfelda2002PlasminogenAI, title={Plasminogen activator inhibitor 1 expression is regulated by the inflammatory mediators interleukin-1alpha, tumor necrosis factor-alpha, transforming growth factor-beta and oncostatin M in human cardiac myocytes.}, author={Karin Macfelda and Thomas Weiss and Christoph Kaun and Johannes M. Breuss and Gerlinde Zorn and Ulrich Oberndorfer and Margit Voegele-Kadletz and Renate Huber-Beckmann and Robert Ullrich and Bernd Binder and Udo M. Losert and Gerald Maurer and R. Pacher and Kurt Huber and Johann Wojta}, journal={Journal of molecular and cellular cardiology}, year={2002}, volume={34 12}, pages={1681-91} }