Plasminogen activator inhibitor-1 as a measure of vascular remodelling in breast cancer.

@article{Fox2001PlasminogenAI,
  title={Plasminogen activator inhibitor-1 as a measure of vascular remodelling in breast cancer.},
  author={Stephen B. Fox and Marian S. Taylor and Jan Gr\ondahl-Hansen and Stylianos Souglakos John Kakolyris and Kevin C. Gatter and Adrian L. Harris},
  journal={The Journal of pathology},
  year={2001},
  volume={195 2},
  pages={236-43}
}
The generation of urokinase plasminogen activator (uPA) by tumours is an important pathway for neoplastic cell invasion and metastasis. Indeed in several tumour types, elevated levels of uPA, its receptor (uPAR) or its inhibitor plasminogen activator inhibitor-1 (PAI-1) is associated with a poorer prognosis. Since endothelial cells also use this proteolytic system to remodel the extracellular matrix during angiogenesis and since angiogenesis, as assessed by microvessel density, is also a… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

Similar Papers

Loading similar papers…