Plasminogen activator inhibitor-1 and apolipoprotein E gene polymorphisms and diabetic angiopathy.


BACKGROUND A point mutation in the plasminogen activator inhibitor-1 (PAI-1) gene and a three-allelic variation in the apolipoprotein-E (ApoE) gene have been suggested as risk factors for the development of diabetic micro- and macrovascular complications. METHODS We studied 198 type 1 diabetic patients with diabetic nephropathy [121 men, age (mean+/-SD… (More)


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