Plasminogen activator inhibitor-1 (PAI-1) content in platelets from healthy individuals genotyped for the 4G/5G polymorphism in the PAI-1 gene.

@article{Nordenhem1997PlasminogenAI,
  title={Plasminogen activator inhibitor-1 (PAI-1) content in platelets from healthy individuals genotyped for the 4G/5G polymorphism in the PAI-1 gene.},
  author={Arvid Nordenhem and Bj{\"o}rn Wiman},
  journal={Scandinavian journal of clinical and laboratory investigation},
  year={1997},
  volume={57 5},
  pages={453-61}
}
We have studied PAI-1 activity and antigen content in platelets and in plasma from 37 healthy individuals who were also genotyped for the 4G/5G polymorphism in the PAI-1 promoter region. The PAI-1 data obtained were compared with the vitronectin and the beta-thromboglobulin contents in platelets from the same individuals. A highly significant correlation between PAI-1 activity and PAI-antigen was obtained, both in the plasma samples (p < 0.0001) and in the platelet lysates (p < 0.001). The… CONTINUE READING

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