Plasminogen activator inhibitor-1 (PAI-1) antigen plasma levels in subjects attending a metabolic ward: relation to polymorphisms of PAI-1 and angiontensin converting enzyme (ACE) genes.

@article{Margaglione1997PlasminogenAI,
  title={Plasminogen activator inhibitor-1 (PAI-1) antigen plasma levels in subjects attending a metabolic ward: relation to polymorphisms of PAI-1 and angiontensin converting enzyme (ACE) genes.},
  author={Maurizio Margaglione and Elvira Grandone and Gennaro Vecchione and Giuseppe Cappucci and Nicola Giuliani and Donatella Colaizzo and Egidio Celentano and Salvatore Panico and Giovanni di Minno},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={1997},
  volume={17 10},
  pages={2082-7}
}
Plasminogen activator inhibitor 1 (PAI-1) is a determinant of vascular events. Subjects in metabolic wards are at high risk for these events. The renin-angiotensin system modulates plasma PAI-1 levels. An insertion (4G)/deletion (5G) polymorphism is involved in the regulation of the circulating levels of PAI-1. We have evaluated the levels of plasma PAI-1 in 208 individuals from our metabolic ward and correlated these levels with the 4G/5G genotype as well as with a genotype (homozygosity for a… CONTINUE READING