Plasminogen activator inhibitor-1, adipose tissue and insulin resistance.

  title={Plasminogen activator inhibitor-1, adipose tissue and insulin resistance.},
  author={M K Alessi and Marjorie Poggi and Ir{\'e}ne Juhan-Vague},
  journal={Current opinion in lipidology},
  volume={18 3},
PURPOSE OF REVIEW Plasminogen activator inhibitor (PAI)-1 is a physiological inhibitor of plasminogen activators (urokinase and tissue types) and vitronectin. It is synthesized by adipose tissue, and its levels in plasma are increased in obesity and reduced with weight loss. Circulating PAI-1 level predicts development of type 2 diabetes, suggesting that it may be causally related to development of obesity. A role for PAI-1 in development of obesity has only partially been established, however… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 67 extracted citations

Similar Papers

Loading similar papers…