Plasminogen activator in mouse and rat oocytes: induction during meiotic maturation.

  title={Plasminogen activator in mouse and rat oocytes: induction during meiotic maturation.},
  author={Joachim Huarte and Dominique Belin and Jean Dominique Vassalli},
  volume={43 2 Pt 1},
We have found that ovulated mouse and rat oocytes contain tissue-type plasminogen activator (PA). Primary oocytes isolated from ovaries did not contain the enzyme. During spontaneous meiotic maturation in vitro, tissue-type PA became detectable 5 hr after germinal vesicle breakdown. Induction of tissue-type PA activity was blocked by dibutyryl-cAMP or isobutylmethyl-xanthine as well as by cycloheximide, but not by actinomycin D or alpha-amanitin. These results suggest that tissue-type PA mRNA… CONTINUE READING


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