Plasminogen Activator Inhibitor-1 in Girls with Precocious Pubarche: A Premenarcheal Marker for Polycystic Ovary Syndrome?

@article{Ibez2002PlasminogenAI,
  title={Plasminogen Activator Inhibitor-1 in Girls with Precocious Pubarche: A Premenarcheal Marker for Polycystic Ovary Syndrome?},
  author={Lourdes Ib{\'a}{\~n}ez and Carles Aulesa and Neus Potau and Ken K Ong and David B Dunger and Francis de Zegher},
  journal={Pediatric Research},
  year={2002},
  volume={51},
  pages={244-248}
}
In both obese and nonobese women, polycystic ovary syndrome (PCOS) is essentially a disorder of hyperinsulinemic insulin resistance, and it may be heralded by precocious pubarche (PP; appearance of pubic hair in girls aged <8 y). The risk of progression from PP to PCOS is related to low birth weight, but there are no early biochemical markers of this risk. As increased plasminogen activator-inhibitor type 1 (PAI-1) activity (act) is an early marker of cardiovascular risk in PCOS, we have sought… CONTINUE READING

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