Plasminogen: purification from human plasma by affinity chromatography.

@article{Deutsch1970PlasminogenPF,
  title={Plasminogen: purification from human plasma by affinity chromatography.},
  author={Dale G. Deutsch and E T Mertz},
  journal={Science},
  year={1970},
  volume={170 3962},
  pages={1095-6}
}
Plasminogen was prepared from human plasma by affinity chromatography on L-lysine-substituted Sepharose. Thirty milligrams of plasminogen, with a specific activity of 100 caseinolytic units (Committee on Thrombolytic Agents) per milligram of nitrogen, were obtained from 340 milliliters of plasma. This corresponds to over 200-fold purification from plasma. Disc-gel electrophoresis at pH 8.3 indicated seven distinct bands, all of which contained activity. 

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