Plasmin-mediated proteolysis is required for hepatocyte growth factor activation during liver repair.

@article{Shanmukhappa2009PlasminmediatedPI,
  title={Plasmin-mediated proteolysis is required for hepatocyte growth factor activation during liver repair.},
  author={Kumar Shanmukhappa and Ursula Matte and Jay L. Degen and Jorge A. Bezerra},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 19},
  pages={12917-23}
}
The physiological relevance of the activation of hepatocyte growth factor (Hgf) by the plasminogen (Plg) system of proteases and its contribution to tissue repair are largely undefined. Here, we investigated whether the defective liver repair in mice lacking Plg is due to impaired activation of Hgf. Loss of Plg in vivo suppressed Hgf activation and signaling through its Met tyrosine kinase receptor. Without Plg, hepatocytes were unresponsive to Hgf-induced proliferation and migration, with a… CONTINUE READING

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