Plasmin-mediated activation and inactivation of thrombin-activatable fibrinolysis inhibitor.

@article{Marx2002PlasminmediatedAA,
  title={Plasmin-mediated activation and inactivation of thrombin-activatable fibrinolysis inhibitor.},
  author={Pauline F. Marx and Philip E. Dawson and Bonno N. Bouma and Joost C M Meijers},
  journal={Biochemistry},
  year={2002},
  volume={41 21},
  pages={
          6688-96
        }
}
Activated thrombin-activatable fibrinolysis inhibitor (TAFIa) attenuates the fibrin cofactor function of tissue-type plasminogen activator-mediated plasmin formation and subsequently fibrin degradation. In the present study, we focused on the role of plasmin in the regulation of TAFIa activity. Upon incubation with plasmin, TAFIa activity was generated, which was unstable at 37 degrees C. Analysis of the cleavage pattern showed that TAFI was cleaved at Arg(92), releasing the activation peptide… CONTINUE READING
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