Plasmin induces smooth muscle cell proliferation.

BACKGROUND Plasminogen activators are routinely used for thrombolysis. They lead to the generation of the protease, plasmin, which can induce smooth muscle cell proliferation and may thus promote further intimal hyperplasia in the thrombolysed vessel. The signaling pathways used by plasmin are not understood. METHODS Murine aortic smooth muscle cells were… CONTINUE READING