Plasmin-induced migration of endothelial cells. A potential target for the anti-angiogenic action of angiostatin.

@article{Tarui2002PlasmininducedMO,
  title={Plasmin-induced migration of endothelial cells. A potential target for the anti-angiogenic action of angiostatin.},
  author={Takehiko Tarui and Mousumi Majumdar and Lindsey A. Miles and Wolfram Ruf and Yoshikazu Takada},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 37},
  pages={
          33564-70
        }
}
Angiostatin, a plasminogen fragment containing 3-4 N-terminal kringle domains, is a potent inhibitor of tumor-induced angiogenesis, but its mechanism of action is unclear. Angiostatin is a ligand for integrin alphavbeta(3) but does not induce stress fiber formation upon integrin binding, suggesting that angiostatin is a potential integrin antagonist. Plasmin, the parent molecule of angiostatin and a major extracellular protease, induces platelet aggregation, migration of peripheral blood… CONTINUE READING

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