Plasmin in urine from patients with type 2 diabetes and treatment-resistant hypertension activates ENaC in vitro.


BACKGROUND Aberrant filtration of plasminogen from plasma and subsequent activation to plasmin in the urinary space may activate proteolytically the epithelial sodium channel, ENaC. In conditions with chronic albuminuria, this may cause hypertension. It was hypothesized that patients with type 2 diabetes mellitus (T2DM) and treatment-resistant hypertension… (More)
DOI: 10.1097/HJH.0000000000000216