Plasmin-dependent proteolysis of tissue factor pathway inhibitor in a mouse model of endotoxemia.

@article{Lupu2013PlasmindependentPO,
  title={Plasmin-dependent proteolysis of tissue factor pathway inhibitor in a mouse model of endotoxemia.},
  author={Cristina Lupu and Oana Herlea and Haiyang Tang and Roger H. Lijnen and Florea Lupu},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2013},
  volume={11 1},
  pages={
          142-8
        }
}
BACKGROUND The development of a procoagulant state in sepsis, owing to aberrant expression of tissue factor (TF) and a sharp decrease in the level of its major inhibitor, TF pathway inhibitor (TFPI), could lead to microthrombotic organ failure. The mechanism for the decline in TFPI activity in the lung could involve plasmin-mediated cleavage of the inhibitor. OBJECTIVE To investigate the effect of plasmin generation on lung-associated TFPI activity, in normal conditions and during infusion of… CONTINUE READING
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