Plasmin degradation of cross-linked fibrin.

  title={Plasmin degradation of cross-linked fibrin.},
  author={Victor J. Marder and Charles W. Francis},
  journal={Annals of the New York Academy of Sciences},
On the basis of structural studies of both degrading insoluble cross-linked fibrin and of soluble derivatives, we have developed a model to explain the principal structural and physical features of plasmic degradation of cross-linked fibrin in vitro from the completely intact matrix to terminally degraded soluble derivatives. The critical event of solubilization occurs only as the result of coincident cleavages at complementary sites in the basic two-stranded half-staggered overlap fibrin… CONTINUE READING
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