Plasmids encoding the mucosal chemokines CCL27 and CCL28 are effective adjuvants in eliciting antigen-specific immunity in vivo

@article{Kutzler2010PlasmidsET,
  title={Plasmids encoding the mucosal chemokines CCL27 and CCL28 are effective adjuvants in eliciting antigen-specific immunity in vivo},
  author={Michele A. Kutzler and Kimberly A. Kraynyak and Sarah J Nagle and Rose M. Parkinson and Darya Zharikova and Michael Chattergoon and Henry H Maguire and Kar Muthumani and Kenneth E Ugen and David B. Weiner},
  journal={Gene Therapy},
  year={2010},
  volume={17},
  pages={72-82}
}
A hurdle facing DNA vaccine development is the ability to generate strong immune responses systemically and at local immune sites. We report a novel systemically administered DNA vaccination strategy using intramuscular codelivery of CCL27 or CCL28, which elicited elevated peripheral IFN-γ and antigen-specific IgG while driving antigen-specific T-cell secretion of cytokine and antibody production in the gut-associated lymphoid tissue and lung. This strategy resulted in induction of long-lived… CONTINUE READING

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