Plasmid rolling circle replication and its control.

  title={Plasmid rolling circle replication and its control.},
  author={Michael P Espinosa and Gloria del Solar and Fernando Rojo and Juan Alonso},
  journal={FEMS microbiology letters},
  volume={130 2-3},
This review summarises current information on rolling circle replicating plasmids originally isolated from Gram-positive bacteria with a low guanine and cytosine content in their DNA. It focuses on the peculiar biological features of these small, high copy number plasmids that replicate via an asymmetric RC mechanism. The regulation of plasmid copy number is also discussed. 
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