Plasmid pUM505 encodes a Toxin-Antitoxin system conferring plasmid stability and increased Pseudomonas aeruginosa virulence.

@article{HernndezRamrez2017PlasmidPE,
  title={Plasmid pUM505 encodes a Toxin-Antitoxin system conferring plasmid stability and increased Pseudomonas aeruginosa virulence.},
  author={K. C. Hern{\'a}ndez-Ram{\'i}rez and V. M. Ch{\'a}vez-Jacobo and M. I. Valle-Maldonado and J. A. Pati{\~n}o-Medina and S. P. D{\'i}az-P{\'e}rez and I. J{\'a}come-Galarza and R. Ort{\'i}z-Alvarado and V. Meza-Carmen and M. I. Ram{\'i}rez-D{\'i}az},
  journal={Microbial pathogenesis},
  year={2017},
  volume={112},
  pages={
          259-268
        }
}
Pseudomonas aeruginosa plasmid pUM505 possesses a pathogenicity island that contains the pumAB genes that encode products with sequence similarity to Toxin-Antitoxin (TA) modules. RT-PCR assays on the overlapping regions of the pumAB genes generated a bicistronic messenger RNA, suggesting that they form an operon. When the pumAB genes were cloned into the pJET vector, recombinant plasmid pJET-pumAB was maintained under nonselective conditions in Escherichia coli cells after six daily… Expand
CrpP Is a Novel Ciprofloxacin-Modifying Enzyme Encoded by the Pseudomonas aeruginosa pUM505 Plasmid

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