Plasmid-mediated and inducible cephalosporinase DHA-2 from Klebsiella pneumoniae.

@article{Fortineau2001PlasmidmediatedAI,
  title={Plasmid-mediated and inducible cephalosporinase DHA-2 from Klebsiella pneumoniae.},
  author={Nicolas Fortineau and Laurent Poirel and Patrice L. Nordmann},
  journal={The Journal of antimicrobial chemotherapy},
  year={2001},
  volume={47 2},
  pages={207-10}
}
A Klebsiella pneumoniae strain resistant to cefoxitin and oxyimino-cephalosporins was cultured from a child hospitalized in Paris, France, in 1992. This isolate harboured a beta-lactamase gene located on an approximately 200 kb non-self-transferable plasmid. The beta-lactamase identified, DHA-2, shared 99% amino acid identity with the AmpC enzyme of Morganella morganii. DHA-2 was a point-mutant derivative of DHA-1 identified previously in a Salmonella enteritidis isolate. DHA-2 expression was… CONTINUE READING

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