Plasmid-encoded proinsulin preserves C-peptide while specifically reducing proinsulin-specific CD8⁺ T cells in type 1 diabetes.

@article{Roep2013PlasmidencodedPP,
  title={Plasmid-encoded proinsulin preserves C-peptide while specifically reducing proinsulin-specific CD8⁺ T cells in type 1 diabetes.},
  author={Bart O Roep and Nanette Solvason and Peter A. Gottlieb and Joana R. F. Abreu and Leonard C. Harrison and George S. Eisenbarth and Liping Yu and Michael Leviten and William A Hagopian and John B Buse and Matthias G von Herrath and Joanne Quan and Robert S King and William H Robinson and Paul Joseph Utz and Hideki Garren and Lawrence Steinman},
  journal={Science translational medicine},
  year={2013},
  volume={5 191},
  pages={191ra82}
}
In type 1 diabetes (T1D), there is an intense inflammatory response that destroys the β cells in the pancreatic islets of Langerhans, the site where insulin is produced and released. A therapy for T1D that targets the specific autoimmune response in this disease while leaving the remainder of the immune system intact, has long been sought. Proinsulin is a major target of the adaptive immune response in T1D. We hypothesized that an engineered DNA plasmid encoding proinsulin (BHT-3021) would… CONTINUE READING

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