Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli.

@article{Papagiannitsis2007PlasmidencodedAA,
  title={Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli.},
  author={Costas C Papagiannitsis and Leonidas S. Tzouvelekis and Eva Tzelepi and Viv{\`i} Miriagou},
  journal={Antimicrobial agents and chemotherapy},
  year={2007},
  volume={51 10},
  pages={3763-7}
}
ACC-4, an omega loop mutant (Val(211)-->Gly) of the Hafnia alvei-derived cephalosporinase ACC-1, was encoded by an Escherichia coli plasmid. The genetic environment of bla(ACC-4) shared similarities with plasmidic regions carrying bla(ACC-1). Kinetics of beta-lactam hydrolysis and levels of resistance to beta-lactams showed that ACC-4 was more effective than ACC-1 against expanded-spectrum cephalosporins. 

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