Plasmid curing and generation of mutations induced with ethidium bromide in streptomycetes.

@article{Crameri1986PlasmidCA,
  title={Plasmid curing and generation of mutations induced with ethidium bromide in streptomycetes.},
  author={Reto Crameri and J. Eric Davies and Ralf Huetter},
  journal={Journal of general microbiology},
  year={1986},
  volume={132 3},
  pages={819-24}
}
The DNA-intercalating agent ethidium bromide was used to eliminate plasmid DNA from streptomycetes. Other mutational events associated with chromosome changes occurred at high frequency; they resulted in phenotypic changes such as loss of enzyme activity, antibiotic resistance or ability to sporulate. 

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