Plasmid-based gene transfer in mouse skeletal muscle by electroporation.

  title={Plasmid-based gene transfer in mouse skeletal muscle by electroporation.},
  author={Jonathan D Schertzer and Gordon S Lynch},
  journal={Methods in molecular biology},
Advances in molecular biology and genetics have provided an abundance of descriptive biological data. Ascribing physiologic roles to these data is an important task to translate this information into improvements in human health. Non-viral transgene delivery of a transgene is a promising approach for defining the physiologic role of a specific protein in vivo. This methodology also has therapeutic potential for the treatment of various diseases. Plasmid DNA injection followed by controlled… CONTINUE READING


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