Plasmid DNA vaccine-elicited cellular immune responses limit in vivo vaccine antigen expression through Fas-mediated apoptosis.

@article{Greenland2007PlasmidDV,
  title={Plasmid DNA vaccine-elicited cellular immune responses limit in vivo vaccine antigen expression through Fas-mediated apoptosis.},
  author={John R Greenland and Ralf Geiben and Sharmistha Ghosh and William A. Pastor and Norman L. Letvin},
  journal={Journal of immunology},
  year={2007},
  volume={178 9},
  pages={5652-8}
}
Particularly potent cellular or humoral immune responses are needed to confer protection in animal models against such pathogens as HIV/SIV, Mycobacterium tuberculosis, and malarial parasites. Persistent, high-level vaccine Ag expression may be required for eliciting such potent and durable immune responses. Although plasmid DNA immunogens are being explored as potential vaccines for protection against these pathogens, little is known about host factors that restrict long-term plasmid DNA… CONTINUE READING
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