Plasmid DNA is superior to viral vectors for direct gene transfer into adult mouse skeletal muscle.

@article{Davis1993PlasmidDI,
  title={Plasmid DNA is superior to viral vectors for direct gene transfer into adult mouse skeletal muscle.},
  author={Heather L. Davis and Barbara A Demeneix and B{\'e}atrice Quantin and Jos{\'e}e Coulombe and R. G. Whalen},
  journal={Human gene therapy},
  year={1993},
  volume={4 6},
  pages={733-40}
}
Direct gene transfer into skeletal muscle offers several therapeutic possibilities. We assessed direct intramuscular injection of recombinant plasmids, adenovirus, or retrovirus in normal or regenerating muscles of mice. The incorporation and expression of reporter genes introduced by any of these three vectors is greater in regenerating than in mature muscle. In regenerating muscle, pure DNA and adenovirus result in equivalent numbers of fibers expressing reporter gene (> 10%), but adenovirus… CONTINUE READING

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