Plasmid DNA-based vaccines protect mice and ferrets against lethal challenge with A/Vietnam/1203/04 (H5N1) influenza virus.

@article{Lalor2008PlasmidDV,
  title={Plasmid DNA-based vaccines protect mice and ferrets against lethal challenge with A/Vietnam/1203/04 (H5N1) influenza virus.},
  author={Peggy A Lalor and Richard R. J. Webby and Jane Morrow and Denis Rusalov and David C Kaslow and Alain Rolland and Larry R Smith},
  journal={The Journal of infectious diseases},
  year={2008},
  volume={197 12},
  pages={1643-52}
}
Plasmid DNA (pDNA) vaccines represent an alternative to conventional inactivated influenza vaccines that are likely to experience supply constraints during a pandemic. Several Vaxfectin-formulated pDNA vaccines were tested in mice and ferrets for efficacy against a lethal challenge with the highly pathogenic A/Vietnam/1203/04 (H5N1) influenza virus strain; the vaccines encoded influenza A virus hemagglutinin (HA), and/or nucleoprotein (NP), and M2 protein. Complete protection from death and… CONTINUE READING

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