Plasmapheresis and immunosuppressive drug therapy in myasthenia gravis.

  title={Plasmapheresis and immunosuppressive drug therapy in myasthenia gravis.},
  author={Peter C. Dau and Jon M. Lindstrom and Christine K. Cassel and Ernest Denys and E E Shev and Lynn E. Spitler},
  journal={The New England journal of medicine},
  volume={297 21},
Plasmapheresis combined with prednisone and azathioprine therapy produced striking clinical improvement in five patients with myasthenia gravis who still had moderate to severe disability despite thymectomy, high-dose prednisone therapy and optimal doses of cholinesterase inhibitors. Serial determinations of titers of serum antibody toward the acetylcholine receptor demonstrated a fall to 21 +/- 5 per cent (mean +/- S.D.) of the original levels concurrently with the patients' increasing… CONTINUE READING
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