Plasmacytoid dendritic cells play a major role in apoptotic leukocyte-induced immune modulation.

@article{Bonnefoy2011PlasmacytoidDC,
  title={Plasmacytoid dendritic cells play a major role in apoptotic leukocyte-induced immune modulation.},
  author={Francis Bonnefoy and Sylvain Perruche and M{\'e}lanie Couturier and Abdeslem Sedrati and Yunwei Sun and Pierre Tiberghien and B{\'e}atrice Gaugler and Philippe Saas},
  journal={Journal of immunology},
  year={2011},
  volume={186 10},
  pages={5696-705}
}
Several APCs participate in apoptotic cell-induced immune modulation. Whether plasmacytoid dendritic cells (PDCs) are involved in this process has not yet been characterized. Using a mouse model of allogeneic bone marrow engraftment, we demonstrated that donor bone marrow PDCs are required for both donor apoptotic cell-induced engraftment and regulatory T cell (Treg) increase. We confirmed in naive mice receiving i.v. syngeneic apoptotic cell infusion that PDCs from the spleen induce ex vivo… CONTINUE READING