Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6.

@article{Jego2003PlasmacytoidDC,
  title={Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6.},
  author={Gaetan Jego and A Karolina Palucka and Jean-Philippe Blanck and C{\'e}cile Chalouni and Virginia Pascual and Jacques Banchereau},
  journal={Immunity},
  year={2003},
  volume={19 2},
  pages={225-34}
}
Dendritic cells (DCs) initiate and control immune responses. Plasmacytoid DCs (pDCs) represent a unique DC subset able to promptly release large amounts of type I interferon (IFN-alphabeta) upon viral encounter. Here we report that depletion of pDCs from human blood mononuclear cells abrogates the secretion of specific and polyclonal IgGs in response to influenza virus. Furthermore, purified pDCs triggered with virus induce CD40-activated B cells to differentiate into plasma cells. Two pDC… CONTINUE READING
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