Plasmacytoid dendritic cells are crucial for the initiation of inflammation and T cell immunity in vivo.

@article{Takagi2011PlasmacytoidDC,
  title={Plasmacytoid dendritic cells are crucial for the initiation of inflammation and T cell immunity in vivo.},
  author={Hideaki Takagi and Tomohiro Fukaya and Kawori Eizumi and Yumiko Sato and Kaori Sato and Azusa Shibazaki and Haruna Otsuka and Atsushi Hijikata and Takashi Watanabe and Osamu Ohara and Tsuneyasu Kaisho and Bernard Malissen and Katsuaki Sato},
  journal={Immunity},
  year={2011},
  volume={35 6},
  pages={958-71}
}
Plasmacytoid dendritic cells (pDCs) are characterized as type I interferon-producing cells that engage endosomal toll-like receptors (TLRs) and exclusively express sialic acid binding Ig-like lectin (Siglec)-H. However, their role in vivo remains unclear. Here we report a critical role for pDCs in the regulation of inflammation and T cell immunity in vivo by using gene-targeted mice with a deficiency of Siglec-H and conditional ablation of pDCs. pDCs were required for inflammation triggered by… CONTINUE READING
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