Plasmacytoid dendritic cells and autoimmune inflammation.

  title={Plasmacytoid dendritic cells and autoimmune inflammation.},
  author={Georgina Galicia and Jennifer Gommerman},
  journal={Biological chemistry},
  volume={395 3},
Plasmacytoid dendritic cells (pDC) are a sub-population of dendritic cells (DC) that produce large amounts of type I interferon (IFN) in response to nucleic acids that bind and activate toll-like-receptor (TLR)9 and TLR7. Type I IFN can regulate the function of B, T, DC, and natural killer (NK) cells and can also alter the residence time of leukocytes within lymph nodes. Activated pDC can also function as antigen presenting cells (APC) and have the potential to prime and differentiate T cells… CONTINUE READING