Plasmacytoid dendritic cells alter the antitumor activity of CpG-oligodeoxynucleotides in a mouse model of lung carcinoma.

@article{Sorrentino2010PlasmacytoidDC,
  title={Plasmacytoid dendritic cells alter the antitumor activity of CpG-oligodeoxynucleotides in a mouse model of lung carcinoma.},
  author={Rosalinda Sorrentino and Silvana Morello and Antonio Luciano and Timothy R. Crother and Piera Maiolino and Eduardo Bonavita and Claudio Arra and Ian M. Adcock and Moshe Arditi and Aldo Pinto},
  journal={Journal of immunology},
  year={2010},
  volume={185 8},
  pages={
          4641-50
        }
}
The effect of CpG-oligodeoxynucleotides (CpG) has been studied on a number of tumors. Although CpG may facilitate tumor regression in mouse models of melanoma, its activity in lung cancer is unclear. The aim of our study was to elucidate the effect of CpG (0.5-50 μg/mouse) in a mouse model of Lewis lung carcinoma cell-induced lung cancer. Lung tumor growth increased at 3 and 7 d after a single administration of CpG. This was associated with a greater influx of plasmacytoid dendritic cells (pDCs… CONTINUE READING

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