Plasmacytoid dendritic cells, interferon signaling, and FcγR contribute to pathogenesis and therapeutic response in childhood immune thrombocytopenia.

@article{Sehgal2013PlasmacytoidDC,
  title={Plasmacytoid dendritic cells, interferon signaling, and FcγR contribute to pathogenesis and therapeutic response in childhood immune thrombocytopenia.},
  author={Kartik Sehgal and Xiuyang Guo and Srinivas Koduru and Anumeha Shah and Aiping Lin and Xiting Yan and Kavita M. Dhodapkar},
  journal={Science translational medicine},
  year={2013},
  volume={5 193},
  pages={193ra89}
}
Immune thrombocytopenia (ITP) is an autoimmune disorder of childhood characterized by immune-mediated destruction of platelets. The mechanisms underlying the pathogenesis of ITP and the therapeutic efficacy of intravenous immunoglobulins (IVIG) in this disorder remain unclear. We show that monocytes from patients with ITP have a distinct gene expression profile, with increased expression of type I interferon response (IR) genes. Plasma from ITP patients had increased levels of several cytokines… CONTINUE READING
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