Plasmacytoid dendritic cells, antigen, and CpG-C license human B cells for plasma cell differentiation and immunoglobulin production in the absence of T-cell help.

@article{Poeck2004PlasmacytoidDC,
  title={Plasmacytoid dendritic cells, antigen, and CpG-C license human B cells for plasma cell differentiation and immunoglobulin production in the absence of T-cell help.},
  author={Hendrik Poeck and Moritz Wagner and Julia Battiany and Simon Rothenfusser and Daniela Wellisch and V. Hornung and Bernd Jahrsdorfer and Thomas Giese and Stefan C. Endres and Gunther Hartmann},
  journal={Blood},
  year={2004},
  volume={103 8},
  pages={3058-64}
}
It has been reported that interferon alpha (IFN-alpha) enhances humoral immunity and that dendritic cells of the myeloid lineage promote B-cell differentiation. Here we studied whether the plasmacytoid dendritic cell (PDC), a subset of dendritic cells specialized for the production of IFN-alpha, is involved in regulating B-cell differentiation and immunoglobulin production. The recently identified class of CpG oligonucleotides (CpG-C) was used to activate both B cells and PDCs via Toll-like… CONTINUE READING