Plasmacytoid DCs regulate recall responses by rapid induction of IL-10 in memory T cells.

  title={Plasmacytoid DCs regulate recall responses by rapid induction of IL-10 in memory T cells.},
  author={Espen O Kvale and Yngvar Fl\oisand and Fridtjof Lund-Johansen and Halvor Rollag and Lorant Farkas and Smita A. Ghanekar and P E R Brandtzaeg and Frode L Jahnsen and Johanna Olweus},
  volume={109 8},
Dendritic cells (DCs) are believed to regulate T cell-mediated immunity primarily by directing differentiation of naive T cells. Here, we show that a large fraction of CD4(+) memory cells produce IL-10 within the first hours after interaction with plasmacytoid DCs (PDCs). In contrast, CD11c(+) DCs induce IFN-gamma and little IL-10. IL-10-secreting T cells isolated after 36 hours of culture with PDCs suppressed antigen-induced T-cell proliferation by an IL-10-dependent mechanism, but were… CONTINUE READING


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