Plasmablasts as Migratory IgG-Producing Cells in the Pathogenesis of Neuromyelitis Optica

  title={Plasmablasts as Migratory IgG-Producing Cells in the Pathogenesis of Neuromyelitis Optica},
  author={Norio Chihara and Toshimasa Aranami and Shinji Oki and Takako Matsuoka and Masakazu Nakamura and Hitaru Kishida and K Yokoyama and Yoshiyuki Kuroiwa and Nobutaka Hattori and Tomoko Okamoto and Miho Murata and Tatsushi Toda and Sachiko Miyake and Takashi Yamamura},
  booktitle={PloS one},
Neuromyelitis optica (NMO) is an inflammatory disease characterized by recurrent attacks of optic neuritis and myelitis. It is generally accepted that autoantibodies against aquaporin 4 water channel protein play a pathogenic role in neuromyelitis optica. We have recently reported that plasmablasts are increased in the peripheral blood of this autoimmune disease, and are capable of producing autoantibodies against aquaporin 4. Here, we demonstrate that CD138(+)HLA-DR(+) plasmablasts, a subset… CONTINUE READING


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