Plasma-volume contraction and exercise-induced hypoxaemia modulate erythropoietin production in healthy humans.

@article{Roberts2000PlasmavolumeCA,
  title={Plasma-volume contraction and exercise-induced hypoxaemia modulate erythropoietin production in healthy humans.},
  author={Delia B Roberts and Daniel J Smith and Sylvia Donnelly and S{\'e}bastien Simard},
  journal={Clinical science},
  year={2000},
  volume={98 1},
  pages={
          39-45
        }
}
This study examined exercise-induced hypoxaemia (EIH) and plasma volume contraction as modulators of serum erythropoietin (Epo) production. Five athletes cycled for 3 min at supra-maximal power outputs, at each of two different elevations (1,000 m and 2,100 m). Five subjects were exposed to normobaric hypoxia (F(I)O(2)=0.159), seven subjects underwent plasmapheresis to reduce plasma volume and eight subjects were time controls for Epo levels. Oxyhaemoglobin saturation was significantly reduced… CONTINUE READING

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