Plasma urate and risk of Parkinson's disease.

  title={Plasma urate and risk of Parkinson's disease.},
  author={Marc A. Weisskopf and Ej O'Reilly and Honglei Chen and Michael A. Schwarzschild and Albert Ascherio},
  journal={American journal of epidemiology},
  volume={166 5},
Oxidative stress contributes to dopaminergic neuron degeneration in Parkinson's disease. Urate, a potent antioxidant, could be neuroprotective. To determine whether higher plasma concentrations of urate predict a reduced risk of Parkinson's disease, the authors conducted a nested case-control study among participants in the Health Professionals Follow-up Study, a cohort comprising over 18,000 men who provided blood samples in 1993-1995. Eighty-four incident cases of Parkinson's disease were… CONTINUE READING

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CSF as well as serum urate are predictors of Parkinson ’ s disease progression

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