Plasma topiramate concentrations resulting from doses associated with neuroprotection against white matter injury and stroke in two strains of rat pups

Abstract

Background:Cerebral white matter (WM) injury and stroke are common neuropathological injuries in newborns with congenital heart defects (CHDs) requiring surgery. Previous investigations in Long Evans rat pups subjected to hypoxia–ischemia found that intraperitoneal (i.p.) topiramate (TPM) at 30 mg/kg, but not 50 mg/kg, conferred neuroprotection. In Sprague… (More)
DOI: 10.1038/pr.2012.194

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@article{Clark2013PlasmaTC, title={Plasma topiramate concentrations resulting from doses associated with neuroprotection against white matter injury and stroke in two strains of rat pups}, author={Annie M. Clark and John T. Mondick and James C. Cloyd and Athena F. Zuppa and Yogendra Sinh H Raol and Robert R. Clancy}, journal={Pediatric Research}, year={2013}, volume={73}, pages={317-324} }