Plasma thrombospondin-1 is increased during acute sickle cell vaso-occlusive events and associated with acute chest syndrome, hydroxyurea therapy, and lower hemolytic rates.

@article{Novelli2012PlasmaTI,
  title={Plasma thrombospondin-1 is increased during acute sickle cell vaso-occlusive events and associated with acute chest syndrome, hydroxyurea therapy, and lower hemolytic rates.},
  author={Enrico M Novelli and Gregory J. Kato and Margaret V Ragni and Yingze Zhang and Mariana E Hildesheim and Mehdi S Nouraie and Suchitra Barge and Michael P Meyer and Andrea L. Cortese Hassett and Victor R Gordeuk and Mark T Gladwin and Jeffrey S. Isenberg},
  journal={American journal of hematology},
  year={2012},
  volume={87 3},
  pages={326-30}
}
Platelets are activated in sickle cell disease (SCD), and particularly during vaso-occlusive episodes (VOE). Thrombospondin-1 (TSP1), a major secretory product of activated platelets, is increased in the circulation in VOE and binds to sickle red blood cells (RBC) promoting vascular adhesion. Thus, we hypothesized that TSP1 may represent a plasma biomarker of disease severity in SCD. We tested the plasma collected from patients in steady state (n = 27) and VOE (n = 14), as well as healthy… CONTINUE READING

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