Plasma thiamine concentrations after intramuscular and oral multiple dosage regimens in healthy men

  title={Plasma thiamine concentrations after intramuscular and oral multiple dosage regimens in healthy men},
  author={M. J. Royer-Morrot and Azz{\'e}dine Zhiri and François Paille and Ren{\'e} Jean Royer},
  journal={European Journal of Clinical Pharmacology},
SummaryA novel liquid chromatographic method for the determination of thiamine in plasma has been developed and has been used to study plasma thiamine concentrations after multiple dosage regimens for 11 days. The method involves purification, concentration and analytical separation of thiochrome on-line, using a switching column system.Ten healthy men were given 500 mg thiamine i.m. once a day (Group 1) and ten were given 250 mg p.o. every 12 h (Group 2). The times to reach steady state (7 and… 

Klinische Untersuchungen zur Pharmakokinetik von Thiaminderivaten

A complex representation of the distribution and interaction of thiamin and its phosphoric acid esters in blood, plasma, and erythrocytes was achieved with the aid of an open multi-compartment model including submodels.

Pharmacokinetics of high-dose oral thiamine hydrochloride in healthy subjects

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Analgesic Effects of Thiamine in Male Long Evans Rats

Background: The concept of analgesic effects of thiamine along with other B vitamins has been supported since long by various clinical and experimental evidences, though effects of individual

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Results clearly showed that feeding a diet containing up to 1.0% thiamin-HCl or 1.

Maternal influences on thiamine status of walleye Sander vitreus ova.

Maternal transfer of thiamine to ova appears to be independent of female ontogenetic or conditional state in S. vitreus, and ova totalThiamine concentration was negatively related to ovum size in some populations, as well as among populations, and was positively related to liver total thienine concentration.

Sensitive and highly selective determination of vitamin B1 in the presence of other vitamin B complexes using functionalized gold nanoparticles as fluorophore

The present work describes the highly selective and sensitive determination of vitamin B1 (thiamine) using 4-amino-6-hydroxy-2-mercaptopyrimidine capped gold nanoparticles (AHMP-AuNPs) by

Effect of thiamine on neuromuscular transmission in smooth muscles

Thiamine and TMP, which are normally present in the extracellular medium, may modulate synaptic transmission, as well as the electrical and contractile activity of the smooth muscles in the gastrointestinal tract.

High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased K(m)): relevance to genetic disease and polymorphisms.

About 50 human genetic dis-eases due to defective enzymes can be remedied or ameliorated by the administration of high doses of the vitamin component of the corresponding coenzyme, which at least partially restores enzymatic activity.

High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased K m ): relevance to genetic disease and polymorphisms 1–3

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Novel Therapies in Acute Kidney Injury

It is concluded that thiamine protects the kidney against the injury and dysfunction caused by I/R.



Tissue thiamin levels of hospitalised alcoholics before and after oral or parenteral vitamins.

The results suggest that except for alcoholics requiring thiamin urgently, for whom the parenteral route is demonstrably quicker at raising tissue levels, oral supplementation achieves the same result as parenTERal.

Determination of thiamine in human plasma and its pharmacokinetics

Thiamine kinetics were studied in plasma and urine from 8 men after intravenous and oral doses of 50, 100 and 200 mg thiamine hydrochloride, demonstrated by plotting the fractional amount of Thiamine excreted unchanged in urine against the corresponding area under the plasma concentration — time curve.

Observations on the mechanism of thiamine hydrochloride absorption in man.

The findings are consistent with the thesis that this vitamin is absorbed by a saturable mechanism and that the number of effective receptor sites may be reduced by malnutrition or intestinal resection.

Jejunal uptake of thiamin hydrochloride in man: influence of alcoholism and alcohol.

It is suggested that neither alcoholism nor acute exposure to alcohol limits jejunal uptake of thiamin hydrochloride, and differences noted between young and old controls need further study.

Oral versus Intramuscular Vitamin Supplementation for Hypovitaminosis in the Elderly

Intramuscular rather than oral vitamin supplementation is a more effective method for maintaining adequate blood levels of vitamins in the elderly and apparently promotes saturation of tissue stores with enough vitamins to meet the needs, and thus obviates problems of vitamin malabsorption possibly due to drug interference or small‐bowel atrophy.

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The method is applicable for drugs which exhibit linear kinetic characteristics not subject to concentration or time‐dependent phenomena, and the estimates of the kinetic parameters are associated with different ranges of possible errors, with total clearance being the most reliable estimate.

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Thiamine transport by human intestine in vitro

Small intestinal mucosa accumulated labelled thiamine in a phosphorylated form, while gastric and colonic mucosa, as well as muscular layers of all gastrointestinal segments studied, did not.

Impairment of thiamine absorption in alcoholism.

A controlled study was undertaken to determine the absorption of radioactive timiamine in a hospitalized group of severely alcoholic patients.