Plasma thiamine concentrations after intramuscular and oral multiple dosage regimens in healthy men

@article{RoyerMorrot2004PlasmaTC,
  title={Plasma thiamine concentrations after intramuscular and oral multiple dosage regimens in healthy men},
  author={M. J. Royer-Morrot and Azz{\'e}dine Zhiri and François Paille and Ren{\'e} Jean Royer},
  journal={European Journal of Clinical Pharmacology},
  year={2004},
  volume={42},
  pages={219-222}
}
SummaryA novel liquid chromatographic method for the determination of thiamine in plasma has been developed and has been used to study plasma thiamine concentrations after multiple dosage regimens for 11 days. The method involves purification, concentration and analytical separation of thiochrome on-line, using a switching column system.Ten healthy men were given 500 mg thiamine i.m. once a day (Group 1) and ten were given 250 mg p.o. every 12 h (Group 2). The times to reach steady state (7 and… 

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