Plasma tetrahydrobiopterin and its pharmacokinetic following oral administration.

  title={Plasma tetrahydrobiopterin and its pharmacokinetic following oral administration.},
  author={Betina Fiege and Diana Ballhausen and Lucja Kierat and Walter Leimbacher and Dimitri Goriounov and Bernhard Schircks and Beat Th{\"o}ny and Nenad Blau},
  journal={Molecular genetics and metabolism},
  volume={81 1},
Tetrahydrobiopterin (BH(4)) is widely used as a therapeutic agent in patients with BH(4) deficiencies and mild forms of phenylketonuria (PKU) and there is an increasing need for the measurement of its plasma concentrations in patients with cardiovascular disorders. We measured BH(4) and total biopterin in dithioerythritol (DTE) pretreated plasma from four adults after oral administration of BH(4) (2, 10, and 20mg/kg body weight) using the differential iodine oxidation method. About 80% (range… CONTINUE READING


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  • N. Blau
  • Th€ ony, J. Vasquez-Vivar, S. Rajagopalan…
  • 2003
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