Plasma surfactant protein-B: a novel biomarker in chronic heart failure.

  title={Plasma surfactant protein-B: a novel biomarker in chronic heart failure.},
  author={Carmine G. De Pasquale and Leonard F. Arnolda and Ian R. Doyle and Philip E. G. Aylward and Derek P B Chew and Andrew D. Bersten},
  volume={110 9},
BACKGROUND In chronic heart failure (CHF), elevated pulmonary microvascular pressure (P(mv)) results in pulmonary edema. Because elevated P(mv) may alter the integrity of the alveolocapillary barrier, allowing leakage of surfactant protein-B (SP-B) from the alveoli into the circulation, we aimed to determine plasma levels of SP-B in CHF and their relation to clinical status. METHODS AND RESULTS Fifty-three outpatients with CHF had plasma SP-B and N-terminal proBNP (NT-proBNP) assayed, in… CONTINUE READING


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Prolonged alveolocapillary barrier damage following acute cardiogenic pulmonary edema

  • CG De Pasquale, LF Arnolda, IR Doyle
  • Crit Care Med
  • 2003

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