Plasma sex hormone concentrations and subsequent risk of breast cancer among women using postmenopausal hormones.

@article{Tworoger2005PlasmaSH,
  title={Plasma sex hormone concentrations and subsequent risk of breast cancer among women using postmenopausal hormones.},
  author={Shelley S. Tworoger and Stacey A. Missmer and Robert L. Barbieri and Walter C. Willett and Graham A. Colditz and Susan E Hankinson},
  journal={Journal of the National Cancer Institute},
  year={2005},
  volume={97 8},
  pages={
          595-602
        }
}
BACKGROUND Sex hormone concentrations are associated with breast cancer risk among women not using postmenopausal hormones (PMH); however, whether a relationship exists among PMH users is unknown. Therefore, we conducted a prospective, nested case-control study within the Nurses' Health Study (NHS) cohort to examine the association between plasma sex hormone concentrations and postmenopausal breast cancer among women using PMH at blood collection. METHODS Blood samples were collected from… 
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It is suggested that the associations of endogenous hormones with postmenopausal breast cancer risk are independent of tumor grade, and hormone receptor status and might increase in strength with age.
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It is reported that high ER but not AR SB is associated with increased breast risk >2 years before diagnosis, and this study provides further evidence on the association of androgens and estrogens with breast cancer.
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Users of systemic E2-containing HRT preparations have plasma E2 and FSH levels comparable to premenopausal women, and NOWAC questionnaires provide valid information on current HRT use and menopausal status among Norwegian women.
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More studies are needed to support the findings for HRT users and to further investigate estrogen levels in relation to estrogen receptor-specific breast cancer and other histological and molecular subtypes.
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Women with lower pr-treatment endogenous estrogen levels were at greater risk of breast cancer during E+P therapy compared with those with higher levels, and the effect of E-P on breast cancer risk was strongest in women whose pretreatment levels of total estradiol, bioavailable estradio, and estrone were in the lowest quartiles.
Serum estrogen and SHBG levels and breast cancer incidence among users and never users of hormone replacement therapy
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More studies are needed to support the findings for HRT users and to further investigate estrogen levels in relation to estrogen receptor-specific breast cancer and other histological and molecular subtypes.
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The findings indicate that in postmenopausal women, mammographic density is independent of circulating sex hormone levels.
menopausal hormone therapy , and breast cancer risk : a nested case-control study in the California Teachers Study cohort Permalink
TLDR
Evidence is found that genetic variation in SLCO1B1 is associated with breast cancer risk in postmenopausal women, particularly among those using combined estrogen-progestin therapy (EPT) at cohort enrollment.
Inclusion of endogenous hormone levels in risk prediction models of postmenopausal breast cancer.
TLDR
The results support that endogenous hormones improve risk prediction for invasive breast cancer and could help identify women who may benefit from chemoprevention or more screening.
Endogenous hormone levels and risk of breast, endometrial and ovarian cancers: prospective studies.
TLDR
A strong positive association between breast cancer risk and circulating levels of both estrogens and testosterone has now been well confirmed among postmenopausal women; women with hormone levels in the top 20% of the distribution (versus bottom 20%) have a two-to-three-fold higher risk of breast cancer.
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